GH/IGF axis

About GH/IGF axis

The peptides in this research area relate to the axis of growth hormone (GH) and insulin-like growth factor IGF-1. They fall into three groups. Analogues of the releasing hormone GHRH are sermorelin, tesamorelin, CJC-1295 and Mod GRF 1-29. Secretagogues described as agonists at the ghrelin receptor GHS-R1a are ipamorelin, GHRP-2, GHRP-6 and hexarelin. Then there are IGF-1 variants and fragments such as IGF-1 LR3, IGF-1 DES, fragment 176-191 and AOD-9604.

For lab work the groups differ clearly. GHRH analogues are fairly long, at 29 to 44 amino acids. The secretagogues are short penta- and hexapeptides containing D-amino acids, which makes them harder for proteases to cleave. CJC-1295 with DAC also carries a group that binds covalently to albumin. Mixes combine a GHRH analogue and a secretagogue in one vial.

Most products come as a lyophilisate in a glass vial, and some fragments also as a spray bottle. Every product page gives sizes and price per mg and, where a source is clear, sequence, molecular formula and CAS number.

Comparisons and further reading

• CJC-1295 vs Ipamorelin
• CJC-1295 vs CJC-1295 + DAC
• Ipamorelin vs GHRP-2
• Sermorelin vs Tesamorelin
• Peptide Nomenclature Explained: Why the Same Substance Has Several Names
• Dissolving peptides: solubility for in vitro work

Common questions