Peptide glossary · Structure and synthesis
Lipidation
Attaching a fatty acid to a peptide, often through a linker on a lysine side chain. The fatty acid mediates binding to albumin. Liraglutide, semaglutide and tirzepatide are lipidated peptides.
In the lab
Lipidated peptides are amphiphilic and more prone to aggregation in solution. Dissolving slowly without shaking and using low-binding tubes helps.
Read moreData comparisonMore terms: Structure and synthesis
- AcetylationAdding an acetyl group, usually at the N-terminus.
- Aib (aminoisobutyric acid)A non-proteinogenic amino acid with two methyl groups on the alpha carbon.
- AmidationReplacing the C-terminal carboxyl group with an amide.
- AnalogueA molecule that resembles a natural model but is changed on purpose, for example by swapping amino acids or adding a side chain.
- C-terminusThe end of a peptide with the free carboxyl group, on the right of the sequence.
- D-amino acidThe mirror image of the natural L-amino acid.
For laboratory research use only. Not for use in humans or animals.